Latest Episode
Triple Agonists: Revolutionizing Weight Loss or Too Much of a Good Thing?
For years, the ceiling on medical weight loss was 15%, maybe 20% if you were lucky. Now a new triple-target medication is posting average results that flirt with 30% body weight loss in clinical trials, numbers once reserved for the operating room. Holly and Jim sat down to unpack what's driving these results, and found themselves asking a question neither expected to ask in their careers: how much weight loss is actually too much?
Retatrutide, the drug at the center of this episode, adds a thi
Recent Episodes
141
Aug. 26, 2026
Triple Agonists: Revolutionizing Weight Loss or Too Much of a Good Thing?
For years, the ceiling on medical weight loss was 15%, maybe 20% if you were lucky. Now a new triple-target medication is posting average results that flirt with 30% body weight loss in clinical trials, numbers once reserved for the operating room. Holly and Jim sat down to unpack what's driving these results, and found themselves asking a question neither expected to ask in their careers: how much weight loss is actually too much? Retatrutide, the drug at the center of this episode, adds a thi
140
Aug. 19, 2026
The Power of Mindfulness for Eating Habits and Weight Management
Can simply paying attention to your first bite of food change how much you eat? It sounds too simple to matter, but Holly and Jim are digging into a topic that might seem completely outside their lane: mindfulness and meditation. For years, mindfulness has been filed under "stress management," not "weight management." But a growing body of research is asking a bigger question: can training the mind actually change the way we eat, not by altering our biology, but by changing how we respond to it
139
Aug. 12, 2026
The Five Minute Prescription: Online GLP-1 Meds and the Future of Obesity Care
A few clicks online. No exam, no phone call, no video visit. Minutes later, a GLP-1 prescription is headed to your door. It sounds like the future of healthcare: fast, easy, convenient. But is convenience the same thing as care? A Yale research team wanted to find out, so they built a fake patient, sent her to 49 different online GLP-1 providers, and tracked exactly what happened. What they found may change the way you think about getting these medications online and raise questions you didn't
138
Aug. 5, 2026
The New Science of Food Noise and Its Impact on Weight Loss
For years, patients kept telling Holly the same strange thing: it wasn't the number on the scale that changed their life, it was something quieter, something they'd never had words for. They just didn't think about food anymore. Now that experience has a name, and for the first time, a way to measure it. Food noise has gone from an offhand comment on social media to one of the most talked-about concepts in obesity science, and Holly and Jim are back to unpack how far the research has come since
137
July 29, 2026
20 Questions That Will Change How You Think About GLP-1s
GLP-1 medications are the single most requested topic on the show, no contest. But with so much noise on social media, in doctors' offices, and everywhere in between, sorting fact from fiction has never been trickier. Some of what's out there is spot-on. Some of it is dangerously wrong. So this week, Holly and Jim are flipping the format. Instead of another lecture, they're putting GLP-1 knowledge to the test with a 20-question quiz covering everything from the basic biology of these medication
136
July 22, 2026
The More You Know, The More You Can Eat with Carolyn O’Neil
We've all felt it: you decide to eat healthier, open social media, and within minutes, you're drowning in contradictory advice. Eggs are back. Butter's healthy. Seed oils are toxic. Never eat after 7pm. Wait, only eat between noon and 6pm? By the end, you're left wondering if anyone can just tell you what to eat. Join Holly and Jim as they sit down with award-winning food journalist and registered dietitian Carolyn O'Neil to unpack why nutrition advice feels so exhausting and contradictory. Wit
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