Latest Episode
Pop Quiz: What Do You Really Know About Keeping Weight Off?
Think you know what it takes to keep weight off? Most people can tell you how to lose weight, but ask them what actually predicts keeping it off, and the answers get shaky fast. That’s a problem, because losing weight and maintaining weight loss are two completely different biological and behavioral games, and confusing the two is one of the biggest reasons people yo-yo.
In this episode, Holly and Jim put their listeners to the test literally. They’ve built a 20-question pop quiz covering every
Recent Episodes
144
Sept. 16, 2026
Pop Quiz: What Do You Really Know About Keeping Weight Off?
Think you know what it takes to keep weight off? Most people can tell you how to lose weight, but ask them what actually predicts keeping it off, and the answers get shaky fast. That’s a problem, because losing weight and maintaining weight loss are two completely different biological and behavioral games, and confusing the two is one of the biggest reasons people yo-yo. In this episode, Holly and Jim put their listeners to the test literally. They’ve built a 20-question pop quiz covering every
143
Sept. 9, 2026
What Should We Eat? Evolution, Diet, and Eating Well with Daniel Lieberman
What did humans actually evolve to eat? With paleo, keto, vegan, Mediterranean, and a thousand other diets all claiming to be "the one," it's no wonder people feel whiplashed every time they walk into a grocery store. But what if the answer isn't found in the latest diet book, but in millions of years of human evolution? Join Holly and Jim as they welcome back Harvard evolutionary biologist Dan Lieberman for a second appearance on the show. This time, Dan isn't talking exercise. He's talking fo
142
Sept. 2, 2026
Ten Key Decisions That Shape Your Weight Loss Success
Most people trying to lose weight obsess over the what: what diet, what medication, what workout plan. But according to Holly and Jim, the real key to long-term success isn't found in any of those choices. It's found in a set of decisions most people never even realize they're making. In this episode, Holly and Jim count down the 10 decisions that determine whether a weight loss journey actually sticks. Some are questions you'd expect. Others might catch you completely off guard, including the
141
Aug. 26, 2026
Triple Agonists: Revolutionizing Weight Loss or Too Much of a Good Thing?
For years, the ceiling on medical weight loss was 15%, maybe 20% if you were lucky. Now a new triple-target medication is posting average results that flirt with 30% body weight loss in clinical trials, numbers once reserved for the operating room. Holly and Jim sat down to unpack what's driving these results, and found themselves asking a question neither expected to ask in their careers: how much weight loss is actually too much? Retatrutide, the drug at the center of this episode, adds a thi
140
Aug. 19, 2026
The Power of Mindfulness for Eating Habits and Weight Management
Can simply paying attention to your first bite of food change how much you eat? It sounds too simple to matter, but Holly and Jim are digging into a topic that might seem completely outside their lane: mindfulness and meditation. For years, mindfulness has been filed under "stress management," not "weight management." But a growing body of research is asking a bigger question: can training the mind actually change the way we eat, not by altering our biology, but by changing how we respond to it
139
Aug. 12, 2026
The Five Minute Prescription: Online GLP-1 Meds and the Future of Obesity Care
A few clicks online. No exam, no phone call, no video visit. Minutes later, a GLP-1 prescription is headed to your door. It sounds like the future of healthcare: fast, easy, convenient. But is convenience the same thing as care? A Yale research team wanted to find out, so they built a fake patient, sent her to 49 different online GLP-1 providers, and tracked exactly what happened. What they found may change the way you think about getting these medications online and raise questions you didn't
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